- #107 [alexanderkoo], 24-03-03 08:29Myself, considered as high. Usually around 110. Taking hot foods. Kid 96/60, too low. Not the lower, the better. Anyway, would have daily fluctuations.
- #106 [0925], 24-03-03 08:19https://www.google.com/search?client=firefox-b-d&q=is+NAC+harmful+to+kidney
N-acetyl-cysteine increases cellular dysfunction in progressive chronic kidney damage after acute kidney injury by dampening endogenous antioxidant responses
Is NAC safe long term?
You may take NAC daily for a short time, but research about the safety of taking NAC every day for the long term is limited. A 2021 literature review found that most studies use it with specific therapeutic goals between 6 weeks and 6 months. Toxicity from NAC intake is rare, particularly in low doses.
Does NAC lower creatinine levels?
NAC has been reported to decrease serum creatinine levels in subjects with normal kidney function. This reduction in serum creatinine was not accompanied by a change in serum cystatin C levels.
Is NAC good for kidneys and liver?
As one of your body's most potent antioxidants, glutathione helps to get rid of cell-damaging free radicals. Reducing oxidative stress can help to lower your risk of developing chronic conditions such as heart disease, diabetes, and infertility. NAC plays a role in the detoxification of your kidneys and liver.
Is it bad to take NAC everyday?
In general, many of the studies using NAC name a standard dosage of 600 milligrams 1-2 times per day. Is it okay to take NAC every day? It should be safe for most adults to take 600 mg of NAC once or twice a day. There are very few side effects associated with taking NAC supplements, and they're pretty rare.
Are there any dangers to taking NAC?
Very high doses (more than 7 grams) of cysteine may be toxic to human cells and may even lead to death. Taking NAC by mouth may cause nausea, vomiting, and diarrhea. Intravenous administration of NAC to treat acetaminophen poisoning may cause severe allergic reactions, including: Angioedema.
Who should avoid taking NAC?
If you have asthma or bleeding problems, your doctor may tell you to avoid NAC. You will likely be told to stop NAC 2 weeks before any elective surgery. If you're pregnant or breastfeeding, you must check with a doctor before using NAC supplements.
Can NAC damage liver?
Taken together, NAC has a dual effect on acute ethanol-induced liver damage. Pretreatment with NAC prevent from acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress. When administered after ethanol, NAC might behave as a pro-oxidant and aggravate acute ethanol-induced liver damage.
Why is NAC banned?
According to the FDA, since NAC was not widely used as a dietary supplement before its use as a drug, it is basically unlawful.
Can NAC raise ALT levels?
NAC can only decrease the serum level of ALT. The relationship between ALT and NAFLD has not been completely explained, but studies support a higher level of ALT as not only a consequence but also a predictor of the development of NASH in these patients [17].
What supplements can cause high creatinine levels?
Creatine supplements: Creatine supplements can increase creatinine levels.
How can I improve my kidney function?
What can I do to keep my kidneys healthy?
Make healthy food choices. ...
Make physical activity part of your routine. ...
Aim for a healthy weight. ...
Get enough sleep. ...
Stop smoking. ...
Limit alcohol intake link. ...
Explore stress-reducing activities. ...
Manage diabetes, high blood pressure, and heart disease.
How much NAC per day is safe?
A common dose of NAC is 600–1,200 mg per day. However, people should discuss the use of NAC and precise dosage with a physician. At least one clinical trial has looked into whether NAC can help children with OCD. Still, current guidelines say that children under the age of 12 should not take NAC.
Is NAC good for fatty liver?
N-Acetylcysteine (NAC), a well-accepted antioxidant, has been shown to protect against high fat diet (HFD)-induced obesity-associated non-alcoholic fatty liver disease (NAFLD) in mice. However, the underlying mechanism(s) of the beneficial role of NAC is still not fully understood.
What happens to your body when you take NAC?
NAC may reduce the risk of heart disease by reducing oxidative damage to tissues in the heart. It has also been shown to increase nitric oxide production, which helps dilate veins and improves blood flow. This helps speed blood flow back to the heart and can reduce the risk of a heart attack.
Does NAC cause high BP?
N-acetyl cysteine might decrease blood pressure. Taking N-acetyl cysteine along with medications for high blood pressure might cause your blood pressure to go too low.
What supplements should you avoid with high creatinine levels?
Some supplements that you should avoid if you have kidney disease include supplements with:
Chromium picolinate.
Creatine monohydrate.
Germanium.
L-lysine.
Larrea tridentate.
Pausinystalia yohimbe.
Salix daphnoides.
Thunder god vine.
Can NAC help repair kidneys?
These results suggested that the renal function of patients with CKD might be improved by NAC use over a three-year duration, although kidney function may not be fully recovered. Table 2. Effect of NAC on the renal function of patients with CKD.
Can you take vitamin C with NAC?
The subjects receiving vitamin C and NAC had higher levels of lipid hydroperoxides and 8-Iso-PGF2alpha 2 d after the exercise. This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress.
Does NAC dissolve kidney stones?
These stones can also be eliminated by dissolution within the kidneys, because the solubility of uric acid is much greater when the pH is above 6. At present, N-acetylcysteine with a urinary basifying agent is the only treatment proposed to increase the dissolution of uric acid stones.
最後修改時間: 2024-03-03 08:22:02 - #105 [0925], 24-03-03 07:35dennis815兄,
Copy & paste 啫唔駛咁客氣。
最後修改時間: 2024-03-03 07:46:33 -
- #104 [alexanderkoo], 24-03-03 06:08It would need a calibrator of 10 times accuracy to calibrate an instrument. The pressure monitor is not self-calibrating. Can check with the doctor's mercury monitor(more accurate if in use) Better buy two for comparison Got three.(2 from amazon.uk, inexpensive) Irrespective of brand, it must have monitoring of irregular heart beat, arrhythmia.
K2 is very useful wrt cardiovascular problem. It only be found in a few types of foods, with vitamin synthesized by special bacteria. It can reallocate calcium away from blood vessel and deposit in suitable place in bone. Calcium supplementation is not necessary.(see the cancelled advertisement for milk powder, a hype)
最後修改時間: 2024-03-03 06:13:04 - #103 [沉默的膏蟹], 24-03-03 05:54Re#97 補充適當維他命可以有幫助.
維他命D3 / K2, B雜, C.
另外盡量食少D糖 .
最後修改時間: 2024-03-03 05:56:34 - #102 [一縷炊煙], 24-03-03 02:59#101 c兄,到底擔心咩啊
- #101 [dennis815], 24-03-03 02:08OMRON,好似話用三、四年後數字會有些微偏差,最好tune機一次
幾年前我朋友帶機去行tune要成三百幾蚊(不如買過部好過)
而且日本製水貨機,行唔知會唔會同你做或者收貴啲
另外,食少啲鹽對減低血壓,我覺得幫助好大
可能依家經濟環境唔好,去茶餐廳食炒小菜,同佢哋講少鹽或者走鹽,好多餐廳都肯做(例牌晚餐除外)
最後修改時間: 2024-03-03 02:19:20 - #100 [dennis815], 24-03-03 02:00#98 謝謝0925師兄!依家都問緊朋友有冇食開膽固醇藥或者睇開嘅內科醫生,嘗試去轉藥。而且一直都有留意身體狀況,每年有做開詳細身體檢查,肝,腎指數
- #99 [一縷炊煙], 24-03-03 01:11今日買,希望俾我一個靚冧把
- #98 [0925], 24-03-03 00:53#93 + 1
7. Severe muscle damage
While rare, simvastatin can cause severe muscle damage, resulting in a serious condition called rhabdomyolysis (横纹肌溶解症) . Rhabdomyolysis can lead to kidney failure if the tissue from the damaged muscle starts clogging up the kidneys.
Muscle pain, along with weakness and tea-colored urine, are the most common indicators of rhabdomyolysis. Contact your healthcare provider right away if you experience these symptoms. You’ll typically need to be treated in a hospital to help protect your kidneys from further damage.
8. Liver damage
Simvastatin can affect your liver, causing changes in your liver tests. This may happen shortly after you start treatment. For most people, these effects don’t cause any noticeable symptoms, and the situation improves or goes away over time. - #97 [dennis815], 24-03-03 00:34#88 約三年前照ct,報告話我血管塞咗約50%,心臟科醫生話再塞到70%左右就要通波仔,開咗隻膽固醇藥畀我,叫我壞膽固醇盡量維持在1.8或以下(果時我都有3.x都幾高),之後我轉左睇政府,食政府隻膽固醇藥
- #96 [0925], 24-03-02 23:48https://www.helsebixen.dk/shop/lekaform-fiskeolie-500-8293p.html
Beskrivelse
1 tablet indeholder 500 mg ren fiskeolie.
Næringsindhold:
Fedtsyrer pr. 3 kapsler:
Omega-3 (n-3) - 450 mg
Heraf:
EPA - 240 mg
DHA - 150 mg
Fiskeoliekapslen er et godt supplement til den daglige vitaminpille og gelatinen er fra ko (Bovine). Indholdet af A- og D-vitamin er ubetydelig.
Anbefalet daglig dosis:
2-5 kapsler dagligt, bør indtages med et glas vand. Daglis dosis bør ikke overskrides. Kosttilskud bør ikke erstatte en varieret kost. Bør kun efter aftale med læge eller sundhedsplejerske anvendes af gravide eller børn under 1 år. Bør opbevares tørt og ikke for varmt, samt utilgængelig for børn.
Ingredienser:
Pligttekst: Den anbefalede daglige dosis bør ikke overskrides. Kosttilskud bør ikke træde i stedet for varieret kost. Bør opbevares uden for små børns rækkevidde.
https://www.matas.dk/lekaform_788333
Ansjos
歐洲鯷為鯷屬的一種,分布於東大西洋區,包括地中海、黑海、亞速海、挪威至南非等海域,棲息深度可達400公尺,本魚吻突出,上頷短,前端圓鈍,體側具一銀色條紋,隨年齡增長而消失,背鰭軟條16-18枚,臀鰭軟條13-15枚,體長可達20公分,棲息沿海、河口,能忍受鹽度的變化,會進行洄游,以浮游生物為食,可做為食用魚或餌魚。 維基百科
學名: Engraulis encrasicolus
最後修改時間: 2024-03-03 00:08:22 - #95 [一縷炊煙], 24-03-02 23:2660零港紙,5知係米毒魚,買咗2樽
- #94 [0925], 24-03-02 22:21https://www.drugs.com/sfx/amlodipine-side-effects.html
呢隻都唔簡單!
Amlodipine Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 11, 2023.
Serious side effects
Other side effects
Professional info
FAQ
Applies to amlodipine: oral solution, oral suspension, oral tablet.
Serious side effects of Amlodipine
Along with its needed effects, amlodipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking amlodipine:
More common
Swelling of the ankles or feet
Less common
Chest tightness
difficult or labored breathing
dizziness
fast, irregular, pounding, or racing heartbeat or pulse
feeling of warmth
redness of the face, neck, arms, and occasionally, upper chest
Rare
Black, tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in the urine or stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
chills
cold and clammy skin
cold sweats
confusion
cough
dark yellow urine
diarrhea
dilated neck veins
dizziness or light headedness when getting up from a lying or sitting position
extra heartbeats
fainting
fever
itching of the skin
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
numbness and tingling of the face, fingers, or toes
pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion
painful or difficult urination
pale, bluish-colored, or cold hands or feet
pinpoint red or purple spots on the skin
red, irritated eyes
redness of the face, neck, arms, and occasionally, upper chest
redness, soreness or itching skin
shakiness in the legs, arms, hands, or feet
slow or irregular heartbeat
sore throat
sores, ulcers, or white spots on the lips or in the mouth
sores, welting, or blisters
sudden sweating
sweating
swelling of the face, fingers, feet, or lower legs
swollen glands
trembling or shaking of the hands or feet
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
weak or absent pulses in the legs
weakness in the arms, hands, legs, or feet
weight gain
yellow eyes or skin
Incidence not known
Clay-colored stools
difficulty with speaking
drooling
headache
loss of appetite
loss of balance control
muscle trembling, jerking, or stiffness
nausea
rash
shuffling walk
stomach pain
twisting movements of the body
uncontrolled movements, especially of the face, neck, and back
unpleasant breath odor
vomiting of blood
yellow eyes or skin
Other side effects of Amlodipine
Some side effects of amlodipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Acid or sour stomach
belching
feeling of warmth
heartburn
indigestion
lack or loss of strength
muscle cramps
redness of the face, neck, arms, and occasionally, upper chest
sleepiness or unusual drowsiness
stomach discomfort, upset, or pain
Rare
Abnormal dreams
anxiety
back pain
bad unusual or unpleasant (after) taste
bleeding gums
blistering, crusting, irritation, itching, or reddening of the skin
bloating
bloody nose
burning feeling in the chest or stomach
burning while urinating
burning, dry, or itching eyes
change in color of the treated skin
change in sense of smell
change in taste
changes in vision
constipation
continuing ringing or buzzing or other unexplained noise in the ears
cracked, dry, or scaly skin
decreased sexual performance or desire
depression
difficulty with moving
difficulty with swallowing
discharge, excessive tearing
double vision
dry mouth
dryness of the skin
excess air or gas in the stomach or intestines
excessive muscle tone
eye pain
feeling of constant movement of self or surroundings
feeling of unreality
feeling unusually cold
flushed, dry skin
fruit-like breath odor
full feeling
general feeling of discomfort or illness
hair loss or thinning of the hair
headache, severe and throbbing
hearing loss
increased appetite
increased hunger
increased sweating
increased thirst
increased urge to urinate during the night
increased urination
irritability
irritation in the mouth
lack of feeling or emotion
loose stools
loss of memory
muscle pains, stiffness, tension, tightness, or weakness
nervousness
pain
pains in the stomach, side, or abdomen, possibly radiating to the back
passing gas
problems with memory
redness and swelling of the gums
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
restlessness
runny nose
seeing double
sensation of spinning
sense of detachment from self or body
shakiness and unsteady walk
shivering
sneezing
stuffy nose
sweating
swollen joints
tenderness in the stomach area
thirst
trouble in holding or releasing urine
trouble sleeping
twitching
uncaring
unexplained weight loss
unsteadiness, trembling, or other problems with muscle control or coordination
waking to urinate at night
weight loss
Incidence not known
Swelling of the breasts or breast soreness in both females and males
For Healthcare Professionals
Applies to amlodipine: oral liquid, oral suspension, oral tablet, oral tablet disintegrating.
General
The most commonly reported side effects include headache, edema, rash, fatigue, and dizziness.[Ref]
Cardiovascular
Myocardial infarction, chest pain, and arrhythmia (e.g., bradycardia, ventricular tachycardia, atrial fibrillation) cannot be distinguished from the natural history of the underlying disease.
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses).[Ref]
Very common (10% or more): Edema (up to 14.6%)
Common (1% to 10%): Palpitations, ankle edema
Uncommon (0.1% to 1%): Hypotension, chest pain
Very rare (less than 0.01%): Myocardial infarction, arrhythmia (including bradycardia, ventricular tachycardia, atrial fibrillation), vasculitis, cardiac failure, pulse irregularity, extrasystoles, hot flush
Frequency not reported: Tachycardia, peripheral ischemia, postural hypotension[Ref]
Nervous system
Common (1% to 10%): Somnolence, dizziness, headache
Uncommon (0.1% to 1%): Tremor, taste perversion/dysgeusia, syncope, hypoesthesia, paresthesia
Very rare (less than 0.01%): Hypertonia, peripheral neuropathy, ataxia, migraine, amnesia, parosmia
Frequency not reported: Extrapyramidal syndrome, postural dizziness, vertigo[Ref]
Headache occurred commonly during clinical trials, especially at the beginning of treatment.
Extrapyramidal syndrome may be associated with this drug.[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting, dyspepsia, altered bowel habits (including diarrhea and constipation), dry mouth
Very rare (less than 0.01%): Pancreatitis, gastritis, gingival hyperplasia, loose stools
Frequency not reported: Dysphagia, flatulence[Ref]
Dermatologic
Common (1% to 10%): Flushing
Uncommon (0.1% to 1%): Alopecia, skin discoloration, increased sweating/hyperhidrosis, pruritus, rash, exanthema
Very rare (less than 0.01%): Erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke edema, photosensitivity, skin dryness, cold and clammy skin, dermatitis[Ref]
Other
Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Tinnitus, asthenia, pain, malaise
Frequency not reported: Rigors, thirst[Ref]
Genitourinary
Uncommon (0.1% to 1%): Micturition disorder, nocturia, increased urinary frequency, impotence
Very rare (less than 0.01%): Dysuria, polyuria
Frequency not reported: Male/female sexual dysfunction[Ref]
Musculoskeletal
Uncommon (0.1% to 1%): Arthralgia, myalgia, muscle cramps, back pain
Very rare (less than 0.01%): Muscle weakness
Frequency not reported: Arthrosis, twitching[Ref]
Psychiatric
Uncommon (0.1% to 1%): Insomnia, mood changes (including anxiety), depression
Rare (0.01% to 0.1%): Confusion
Frequency not reported: Abnormal dreams, depersonalization, nervousness, apathy, agitation[Ref]
Respiratory
Uncommon (0.1% to 1%): Dyspnea, rhinitis
Very rare (less than 0.01%): Cough
Frequency not reported: Epistaxis[Ref]
Ocular
Uncommon (0.1% to 1%): Visual disturbance (including diplopia)
Very rare (less than 0.01%): Abnormal visual accommodation, xerophthalmia
Frequency not reported: Abnormal vision, conjunctivitis, eye pain[Ref]
Metabolic
Uncommon (0.1% to 1%): Weight increase/decrease
Very rare (less than 0.01%): Hyperglycemia, increased appetite
Frequency not reported: Anorexia[Ref]
Hematologic
Uncommon (0.1% to 1%): Purpura
Very rare (less than 0.01%): Leukopenia, thrombocytopenia[Ref]
Endocrine
Uncommon (0.1% to 1%): Gynecomastia[Ref]
Hepatic
Increased hepatic enzymes were mostly consistent with cholestasis.
Some cases of hepatitis, jaundice, and/or hepatic enzyme elevations were severe enough to require hospitalization; however, the association with this drug was uncertain in most cases.[Ref]
Very rare (less than 0.01%): Hepatitis, jaundice, hepatic enzymes increased[Ref]
Hypersensitivity
Very rare (less than 0.01%): Allergic reactions, angioedema[Ref] - #93 [0925], 24-03-02 21:40https://www.goodrx.com/simvastatin/simvastatin-side-effects
原來呢隻藥唔簡單!
9 Simvastatin Side Effects You Should Know About
Brian Leonard, PharmD, BCACP, BCGP
Austin Ulrich, PharmD, BCACP
Written by Brian Leonard, PharmD, BCACP, BCGP | Reviewed by Austin Ulrich, PharmD, BCACP
Published on July 24, 2023
Key takeaways:
Simvastatin (Zocor) is a prescription-only statin medication. It’s used to treat high cholesterol from different causes, including inherited, or passed-down, conditions. It can also lower the risk of heart attack and stroke for people who are at a high risk.
Common simvastatin side effects include upper respiratory infections, headaches, and abdominal pain. Constipation, nausea, and muscle pain are also possible. More serious side effects include severe muscle damage and liver problems.
Most simvastatin side effects are mild and can be managed at home. But muscle pain that’s accompanied by weakness and dark-colored urine requires medical attention.
Access savings to related medications
Simvastatin
Flolipid
Zocor
Table of contents
A custom graphic includes a light-pink background with a warning sign pattern and an oblong, peach pill cut into three parts.
GoodRx Health
Simvastatin (Zocor) is in a class of prescription medications called statins. You may have heard that it can have beneficial effects on your cholesterol levels, heart, and blood vessels. But you also may have heard that it can cause troubling side effects, like muscle pain.
While this is true, muscle pain from statins isn’t as common as you may think. And there are several ways to manage it, including possibly adjusting the dose of your medication. Other common side effects of statins include headaches, abdominal pain, and constipation.
Keep in mind that most people taking statins don’t report any side effects. But if you do experience side effects, it’s important to know how to manage them and, if necessary, when to get medical care. Below, we review what you should know about nine potential simvastatin side effects.
1. Upper respiratory infections
Upper respiratory infections (URIs) are a commonly reported simvastatin side effect. These infections may cause symptoms like a runny or stuffy nose, sore throat, and cough.
URIs are usually caused by viruses and start to resolve within 10 days on their own. In the meantime, you may be able to ease your symptoms with over-the-counter (OTC) cold and flu medications.
If you’re not feeling any better by Day 10, your infection may be caused by bacteria. In this case, you may need to take an antibiotic to treat the infection. If you develop a fever that lasts for several days, chest pain, or shortness of breath, contact your healthcare provider right away.
2. Headache
Headaches are another common simvastatin side effect. They may subside as your body gets used to the medication. But it’s important to keep in mind that headaches can have several other causes.
If your headaches become bothersome, your healthcare provider may suggest that you try an OTC pain reliever. There are also some home remedies that may help relieve the pain. But if the headaches are severe or don’t go away, let your provider know.
Go to the nearest emergency room if your headache is accompanied by confusion or fainting, if it feels unusually or extremely painful, or it gets worse when you’re lying down.
3. Abdominal pain
Another common simvastatin side effect is abdominal pain. Since abdominal pain can be caused by several different things, it’s important to let your provider know if it occurs. Pay close attention to where on your body the pain is coming from.
Abdominal pain that’s accompanied by other symptoms, like yellowing of the skin and eyes (jaundice) and swelling, can be a sign of something more serious. Contact your provider right away if this occurs. And if your abdominal pain is severe, go to the nearest emergency room.
4. Constipation
Some people experience constipation while taking simvastatin. Drinking plenty of fluids, eating fiber, and staying active can help prevent or relieve constipation. If these changes don’t provide relief, talk to your pharmacist about giving OTC laxatives a try. They can help you find the best option to get things moving again.
If your constipation becomes painful or doesn’t seem to be letting up, contact your healthcare provider. They can help you determine if something else is causing your constipation and how you can resolve it.
5. Nausea
You may experience nausea when taking simvastatin, which can be taken with or without food. If the medication is making you feel nauseous, try taking your doses with a small meal or snack to see if that helps.
If your nausea continues or you experience vomiting, contact your healthcare provider. They can help you determine what’s causing your nausea and how to manage your symptoms. In some cases, your provider may recommend an anti-nausea medication to help you get some relief.
6. Muscle pain
Muscle symptoms, including muscle pain, are commonly reported by people taking simvastatin and other statins. However, recent evidence suggests that the muscle pain isn’t actually being caused by the statin in most cases. When statin-induced muscle pain does occur, it may be more likely to affect people who are taking higher statin doses, age 65 or older, or have kidney problems.
Taking simvastatin with certain medications that interact with it can also increase the risk of muscle pain. You may need to take a lower simvastatin dose if you’re also taking one of these medications. Common examples of these medications are amlodipine (Norvasc) and verapamil.
If you’re experiencing muscle pain while taking simvastatin, let your healthcare provider know. They can help you determine the cause of the pain and potential next steps. Oftentimes, lowering the dose of simvastatin or temporarily taking a break from the medication can help people stick with treatment. Your provider might also suggest taking a different statin that may have a lower risk of muscle pain.
7. Severe muscle damage
While rare, simvastatin can cause severe muscle damage, resulting in a serious condition called rhabdomyolysis. Rhabdomyolysis can lead to kidney failure if the tissue from the damaged muscle starts clogging up the kidneys.
Muscle pain, along with weakness and tea-colored urine, are the most common indicators of rhabdomyolysis. Contact your healthcare provider right away if you experience these symptoms. You’ll typically need to be treated in a hospital to help protect your kidneys from further damage.
8. Liver damage
Simvastatin can affect your liver, causing changes in your liver tests. This may happen shortly after you start treatment. For most people, these effects don’t cause any noticeable symptoms, and the situation improves or goes away over time.
But in rare cases, serious liver damage is possible. If you have a history of liver problems or drink large amounts of alcohol, you may have a higher risk of liver damage from simvastatin.
If you notice signs or symptoms of liver damage, contact your provider right away. You should look out for:
Loss of appetite
Abdominal pain
Dark-colored urine
Weakness or fatigue
Yellowing of your skin or eyes
9. Increased blood sugar levels
Simvastatin is often used to lower the risk of heart attack and stroke in certain people with diabetes. But it can also increase blood glucose (sugar) levels. This is because statins may interfere with how well insulin works in your body.
If you have diabetes, you may have higher blood glucose levels while taking simvastatin. So your healthcare provider may want to keep a close eye on your levels during treatment. If you have diabetes risk factors, simvastatin may increase your risk of developing diabetes. But regular exercise and a diabetes-friendly diet can help minimize this risk.
Keep in mind: Simvastatin’s cardiovascular benefits often outweigh the potential risk of new or worsening diabetes. In fact, taking a statin is recommended for many people who have diabetes. If you have questions about your treatment plan, talk to your healthcare provider.
When should you contact your healthcare provider about simvastatin side effects?
Most simvastatin side effects are mild and can be managed at home. But you should contact your healthcare provider if you have side effects that are bothersome or concerning. Your care team can help you figure out how best to treat your symptoms. And some side effects, like changes in liver tests and increased blood glucose levels, may need to be monitored as part of your routine follow-up care.
In particular, side effects like muscle pain with weakness and tea-colored urine shouldn’t be ignored. Abdominal pain with yellowing of the skin and eyes can also be a sign of something more serious. Contact your healthcare right away if these symptoms occur.
The bottom line
Common simvastatin (Zocor) side effects include upper respiratory infections, headaches, and abdominal pain. Constipation, nausea, and muscle pain are also possible. While rare, serious simvastatin side effects can include severe muscle damage and liver damage.
If you have concerns about any simvastatin side effects, speak with your healthcare provider or pharmacist. They can help you pinpoint the potential cause of your side effects and suggest next steps.
References
Bryant Ranch Prepack. (2023). Simvastatin - simvastatin tablet, film coated [package insert].
Centers for Disease Control and Prevention. (2023). Statins and diabetes: What you should know.
View All References (4)
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines. - #92 [0925], 24-03-02 21:33https://helloyishi.com.tw/drugs-supplement/simvastatin/
辛伐他汀(Simvastatin)
辛伐他汀有哪些用途?
辛伐他汀的注意事項與使用禁忌
使用辛伐他汀的潛在副作用
使用辛伐他汀的潛在交互作用
辛伐他汀的建議用量
辛伐他汀有哪些用途?
辛伐他汀(Simvastatin,商品名:維妥力)是用在降低血液中的膽固醇和三酸甘油酯。它還用來降低患有糖尿病、冠狀動脈疾病或其他危險因素的患者,可能產生中風、心臟病以及其他心臟併發症的風險。辛伐他汀可用在成年人和10歲以上的兒童。
該怎麼服用辛伐他汀呢?
辛伐他汀是一種口服錠。一般來說每天晚上服用一次。且在每天大約同一的時間裡服用辛伐他汀。並請遵照醫師來服用辛伐他汀。醫師可能會從低劑量的辛伐他汀開始開立處方,並逐漸增加劑量,每4週不會多於一次。另外,請勿在沒有與醫師討論之下,就貿然停止服用辛伐他汀。
如何存放辛伐他汀?
辛伐他汀最好存放在室溫底下,且避免直接陽光照射和潮濕環境。為防止藥物壞掉,不應該將辛伐他汀存放在浴室中或冷藏室裡。不同品牌的辛伐他汀可能有不同的存儲方式。請務必仔細查看產品包裝中的保存說明,或詢問藥師。另外,為了安全起見,您應該將所有藥物遠離兒童和寵物。
辛伐他汀的注意事項與使用禁忌
使用辛伐他汀安全嗎?
在開始服用此藥物之前,請與醫師討論這些假設情況:
您是否懷孕或有在哺乳。因為若您正在懷孕或哺乳嬰兒,您只能在醫生的建議下服用此藥物。
您正在服用任何其他藥物,包括:西藥、草藥,和其他補充藥品。
您有對任何辛伐他汀,或其他藥物的活性或非活性成分過敏。
您有任何其他的疾病,失調或內科疾病。
您患有肝臟疾病。 即使您不認為自己患有肝臟疾病,但醫師仍可能依判斷檢查血液,看看肝臟的運作情形。醫師很可能會告訴您不要服用辛伐他汀,如果您患有肝臟疾病,或者假設檢測結果顯示您可能患有肝臟疾病。
如果您是65歲或以上的人,且每天喝上2杯以上的酒精飲料。
您目前正有手術療程,包括牙科手術。
您因為嚴重受傷或感染而住院治療。
向您的醫生詢問有關於酒類飲料的安全飲用方式,當您在服用辛伐他汀時。因為酒精會增加嚴重副作用的風險。
在懷孕或哺乳期間服用辛伐他汀是否安全?
目前是沒有足夠的研究,來針對女性去確認在懷孕期間或親餵哺乳期間,是否使用辛伐他汀時會造成風險。在服用辛伐他汀之前,請務必諮詢醫生,來評估您潛在的益處和風險。根據美國食品藥物管理局(FDA)的分類,辛伐他汀是妊娠風險中的類別X。
美國食品藥物管理局(FDA)的妊娠風險類別參考如下:
A =無風險,
B =部分研究顯示是無風險,
C =可能存在一些風險,
D =研究證實有風險,
X =禁忌,
N =未知
使用辛伐他汀的潛在副作用
辛伐他汀可能會產生副作用。如果以下這些症狀是很嚴重或者不會停止的話,請一定要告訴醫師:
便秘
胃痛
噁心
頭痛
記憶喪失或健忘
混淆
而一些副作用可能會很嚴重。如果您出現以下任何症狀的話,請盡快就醫或尋求急診。
肌肉痛、觸痛或虛弱
暗紅色的尿液
排尿量減少
缺乏動力、疲倦或虛弱
食慾不振
胃的右上部分感覺疼痛
皮膚或眼睛發黃
發燒或寒顫
發紅
有水皰
起疹子
蕁麻疹
搔癢
臉部、喉嚨、舌頭、嘴唇、眼睛、手、腳、腳踝或小腿腫脹
吞嚥或呼吸困難
嘶啞
關節痛
對光線敏感
不是每個人都會有這些副作用發生。但也可能發生上面未提及的一些副作用。如果您對副作用有任何疑慮,請諮詢醫師或藥師。
使用辛伐他汀的潛在交互作用
什麼藥物會與辛伐他汀交互作用?
辛伐他汀可能會與您目前服用的其他藥物相互作用,這可能會使藥物的功效改變,或者增加嚴重副作用的風險。為了避免與任何潛在藥物的相互作用,您應該保留所有您目前服用藥物的處方清單,包括處方藥、非處方藥和草本藥物,並與醫師、藥師討論。為了您的安全,未經醫生批准或指示,不要開始服用、停止服用或更改任何藥物的劑量。
可能會與此藥物相互作用的產品包括有:
抗黴菌藥物,如伊曲康唑 Itraconazole (商品名:Sporanox)、酮康唑 Ketoconazole(商品名:Nizoral),泊沙康唑 Posaconazole (商品名:Noxafil),以及伏立康唑 Voriconazole (商品名:Vfend)
蛋白酶抑制劑 Boceprevir(商品名:Victrelis)
克拉黴素 Clarithromycin (商品名:Biaxin、Prevpac)
含有 Cobicistat 的藥物,例如:愛滋新藥:Stribild
環孢黴素 Cyclosporine(商品名:Gengraf、Neoral、Sandimmune)
丹那唑 Danazol
紅黴素 Erythromycin(商品名:E.E.S.、E-Mycin、Erythrocin)。
吉非羅齊 Gemfibrozil(商品名:Lopid)
HIV蛋白酶抗化劑,如:阿扎那韋 Atazanavir(商品名:Reyataz)、地瑞那韋 Darunavir(商品名:Prezista)、福沙那韋 Fosamprenavir(商品名:Lexiva)、茚地那韋 Indinavir(商品名:Crixivan)、洛匹那韋 Lopinavir(商品名:Kaletra)、甲磺酸萘非那韋 Nelfinavir(商品名:Viracept)、利托那韋 Ritonavir(商品名:Norvir、Kaletra)、沙奎那韋 Saquinavir(商品名:Invirase)、和替拉那韋 Tipranavir(商品名:Aptivus)
奈法唑酮 Nefazodone
替拉瑞韋 Telaprevir((商品名:Incivek)
泰樂黴素 Telithromycin((商品名:Ketek)
胺碘酮 Amiodarone((商品名:Cordarone、Pacerone)
氨氯地平 Amlodipine(商品名:Norvasc、Caduet,Lotrel)
抗凝血藥物 Anticoagulants(即血液稀釋劑),如:華法林 Warfarin(商品名:Coumadin、Jantoven)、秋水仙素 Colchicine (商品名:Colcrys)
地高辛 Digoxin(商品名:Digitek、Lanoxicaps、Lanoxin)
地爾硫卓 Diltiazem(商品名:Cardizem、Dilacor、Tiazac)
決奈達隆 Dronedarone(脈泰克膜衣錠 Multaq)
其他降膽固醇藥物,如:弗尼利脂寧 Fenofibrate(商品名:Tricor)、 微粒體三酸甘油酯轉移蛋白抑制劑 Lomitapide(商品名:Juxtapid)和菸鹼酸 Niacin(商品名:Nicotinic acid、Niacor、Niaspan)
雷諾嗪 Ranolazine(商品名:Ranexa)
維拉帕米 Verapamil(商品名:Calan、Covera、Isoptin、Verelan)
酒精會與辛伐他汀相互作用嗎?
辛伐他汀可透過與食物或酒精的相互作用來改變藥效方式,或增加嚴重副作用的風險。 在使用此藥物之前,請與您的醫師或藥師討論有關任何食物或酒精相互作用的問題。
辛伐他汀可能與您的健康狀況相互作用。 這種相互作用很可能惡化健康狀況,或改變藥效方式。 您必須隨時告知醫師您的健康狀況,例如:
甲狀腺功能低下
糖尿病
癲癇發作
肌肉酸痛或虛弱
低血壓
腎臟疾病
辛伐他汀的建議用量
這裡所提供的訊息不能代替任何醫療的建議。所以在服用辛伐他汀之前,請先諮詢醫師或藥師。
辛伐他汀對成人的劑量是多少?
一般通常的劑量範圍大概是5至40毫克(mg)/天。而對於患有冠狀動脈疾病或高風險冠狀動脈疾病的患者們,辛伐他汀是可以和飲食同時地服用。 建議一般開始的劑量是10或20毫克(mg)。
而存有冠狀動脈疾病、糖尿病、周邊動脈疾病、中風史或其他腦血管疾病而導致冠狀動脈疾病情況處於高風險的患者,建議的開始劑量為40毫克(mg)/天。並且,應在治療4週後進行脂肪檢測,之後定期性檢測。
辛伐他汀對小孩的劑量是多少?
服用的劑量尚未在小兒科患者中得到確認。但這可能對您的孩子有些不安的風險。所以一定要在使用前充分了解藥物的安全性。並請與您的醫生或藥劑師諮商來獲得更多的相關訊息。
如何取得辛伐他汀?
辛伐他汀有以下劑型和濃度:
錠裝
該怎麼處理如果發生緊急或服用過量的情況?
如果發生緊急狀況或服用過量時,請致電119或前往最近的急診室。
如果錯過服用該怎麼辦?
如果您錯過了一劑辛伐他汀,請盡快服用。 但是,如果接近您下次劑量的時間,請跳過錯過的劑量並按計劃服用正常的劑量。請不要服用雙倍劑量。 - #91 [0925], 24-03-02 21:29https://www.mayoclinic.org/drugs-supplements/simvastatin-oral-route/side-effects/drg-20069006
Side Effects
Drug information provided by: Merative, Micromedex®
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Dizziness
fainting
fast or irregular heartbeat
Less common
Bladder pain
bloody or cloudy urine
blurred vision
body aches or pain
chills
cough
dark-colored urine
difficult, burning, or painful urination
difficulty with breathing
difficulty with moving
dry mouth
ear congestion
fever
flushed, dry skin
frequent urge to urinate
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
joint pain
loss of consciousness
lower back or side pain
muscle cramps, spasms, stiffness, pain, tenderness, wasting, or weakness
nausea
runny or stuffy nose
sneezing
sore throat
stomachache
sweating
swelling
swollen joints
trouble breathing
unexplained weight loss
unusual tiredness or weakness
vomiting
Incidence not known
Blistering, peeling, or loosening of the skin
bloating
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest tightness
constipation
diarrhea
difficulty with chewing, swallowing, or talking
double vision
drooping eyelids
general tiredness and weakness
indigestion
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of appetite
muscle pain or weakness
pains in the stomach, side, or abdomen, possibly radiating to the back
pale skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
red, irritated eyes
skin rash, hives, or itching
sores, ulcers, or white spots in the mouth or on the lips
unusual bleeding or bruising
upper right abdominal or stomach pain
weakness in the arms, hands, legs, or feet
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Acid or sour stomach
belching
burning feeling in the chest or stomach
dizziness or lightheadedness
excess air or gas in the stomach or intestines
feeling of constant movement of self or surroundings
full feeling
heartburn
lack or loss of strength
pain or tenderness around the eyes and cheekbones
passing gas
sensation of spinning
skin rash, encrusted, scaly, and oozing
stomach discomfort, upset, or pain
tenderness in the stomach area
trouble sleeping
Incidence not known
Being forgetful
depression
discoloration of the skin
hair loss or thinning of the hair
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. - #90 [0925], 24-03-02 21:21https://www.drugs.com/simvastatin.html
Warnings
In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication.
Some medicines can cause unwanted or dangerous effects when used with simvastatin.
____________________________________________________________________
What is simvastatin?
Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."
Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).
Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.
Simvastatin is used in adults and children who are at least 10 years old.
Warnings
In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects.
Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.
Simvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant or planning to become pregnant.
Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication.
Some medicines can cause unwanted or dangerous effects when used with simvastatin. Your doctor may need to change your treatment plan if you use certain antibiotics or antifungal medicines, hepatitis C medication, heart medication, or medicines to treat HIV/AIDS.
Stop taking this medication and tell your doctor right away if you become pregnant.
Before taking this medicine
You should not take this medicine if you are allergic to simvastatin, or if:
you have active liver disease; or
you are pregnant or breastfeeding.
The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. These drugs should not be used while you are taking this medicine:
cyclosporine;
danazol;
gemfibrozil;
nefazodone;
an antibiotic - clarithromycin, erythromycin, telithromycin;
antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole;
hepatitis C medications - boceprevir, telaprevir; or
HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.
Before you start taking simvastatin, tell your doctor if you are already using any of these other medicines:
lomitapide; or
heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.
To make sure simvastatin is safe for you, tell your doctor if you have:
history of liver disease;
history of kidney disease;
diabetes;
a thyroid disorder; or
if you drink more than 2 alcoholic beverages daily.
Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).
This medicine can harm an unborn baby or cause birth defects. Do not take simvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.
Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking this medicine.
Simvastatin pregnancy and breastfeeding warnings (more detail)
How should I take simvastatin?
Take simvastatin exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.
Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.
While using simvastatin, you may need frequent blood tests at your doctor's office.
You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.
Simvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture, heat, and light.
Detailed Simvastatin dosage information
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What to avoid
Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.
Avoid eating foods that are high in fat or cholesterol. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Simvastatin side effects
Get emergency medical help if you have signs of an allergic reaction to simvastatin (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Simvastatin can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine.
Also call your doctor at once if you have:
signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or
muscle weakness in your hips, shoulders, neck, and back;
trouble lifting your arms, trouble climbing or standing; or
liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common simvastatin side effects may include:
headache;
constipation, nausea, stomach pain; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Simvastatin side effects (more detail)
What other drugs will affect simvastatin?
Many drugs can interact with simvastatin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment, especially:
delavirdine;
fenofibrate; or
fluconazole.
This list is not complete and many other drugs can interact with simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
最後修改時間: 2024-03-02 21:28:30 - #89 [ovator], 24-03-02 21:17Omron HEM-7156
Quite a few clinics in HK use this brand and this specific model.
More importantly, you need to use it in the right posture. Else results won't be accurate anyways. - #88 [沉默的膏蟹], 24-03-02 21:10Re#77
你血壓咁好, 真係可以考慮唔使食膽固醇藥. 血壓標準已經代表你血管唔差, 唔使太擔心膽固醇影響. 你依家膽固醇仲係偏高?
我睇過好多好多段片呢隻膽固醇藥好大副作用,我次次覆診攞完都係等過期.
最後修改時間: 2024-03-02 21:11:53 - 下一頁 (3 of 8)
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